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Table 1 NIRS variables at end point between placebo and loratadine during +Gz exposure with GOR and ROR.

From: A new evaluation method for +Gz tolerance with loratadine by using a near-infrared spectroscopy

 

GOR

ROR

NIRS Variable

Relaxed

Straining

Straining

 

Placebo

Loratadine

Placebo

Loratadine

Placebo

Loratadine

ΔO 2 Hb (μmol·L -1 )

-10.5 ± 5.6

-11.1 ± 5.7

-17.4 ± 8.1

-16.9 ± 7.4

-14.7 ± 7.2

-15.0 ± 6.4

ΔHHb (μmol·L -1 )

0.5 ± 2.4

-0.1 ± 3.4

2.8 ± 1.2

1.4 ± 4.6

0.7 ± 3.0

1.9 ± 3.7

ΔcHb (μmol·L -1 )

-11.3 ± 6.8

-12.8 ± 8.6

-13.2 ± 6.8

-15.5 ± 12.6

-13.6 ± 7.0

-12.0 ± 7.6

TOI%

67.6 ± 4.5

70.2 ± 6.4

64.8 ± 3.7

67.2 ± 6.9

63.5 ± 4.8

66.3 ± 5.7

Baseline

72.4 ± 4.7

73.6 ± 5.1

  

72.2 ± 4.9

73.7 ± 4.7

ΔTOI%

-4.8 ± 2.5

-3.3 ± 3.2

-7.6 ± 2.2

-6.4 ± 4.0

-8.8 ± 1.5

-7.4 ± 3.1

  1. Values are means ± standard deviation. NIRS: near-infrared spectroscopy, GOR: gradual onset run, ROR: rapid onset run, O2Hb: oxygenated hemoglobin, HHb: deoxygenated hemoglobin, cHb: O2Hb + HHb, TOI: tissue oxygenation index, Δ: change.