Comparison of two normative paediatric gait databases
- Victoria L Chester^{1}Email author,
- Maureen Tingley^{2} and
- Edmund N Biden^{3}
DOI: 10.1186/1476-5918-6-8
© Chester et al; licensee BioMed Central Ltd. 2007
Received: 08 June 2006
Accepted: 17 July 2007
Published: 17 July 2007
Abstract
The availability of age-matched normative data is an essential component of clinical gait analyses. Comparison of normative gait databases is difficult due to the high-dimensionality and temporal nature of the various gait waveforms. The purpose of this study was to provide a method of comparing the sagittal joint angle data between two normative databases. We compared a modern gait database to the historical San Diego database using statistical classifiers developed by Tingley et al. (2002). Gait data were recorded from 60 children aged 1–13 years. A six-camera Vicon 512 motion analysis system and two force plates were utilized to obtain temporal-spatial, kinematic, and kinetic parameters during walking. Differences between the two normative data sets were explored using the classifier index scores, and the mean and covariance structure of the joint angle data from each lab. Significant differences in sagittal angle data between the two databases were identified and attributed to technological advances and data processing techniques (data smoothing, sampling, and joint angle approximations). This work provides a simple method of database comparison using trainable statistical classifiers.
Background
One of the main objectives of gait analysis is to identify deviations in a patient's gait from 'normal' movement patterns. A critical component of gait analysis therefore, is the availability of age-matched normative databases. Researchers of paediatric gait typically develop their own normative databases or refer to published data. Substantial data on temporal-spatial [1–6] and kinematic parameters [7–10] are available in the literature for paediatric gait. Existing trunk kinematic [11] and joint kinetic [12–18] databases tend to consist of small sample sizes and are sparser in the literature.
Until recently, we used a database that was developed at the Children's Hospital, San Diego [2]. This large database contains temporal-spatial and joint angle data for 409 gait cycles for children aged 1.0 to 7.0 years old. Trunk and kinetic data were not available in this database. Difficulties in comparing patient data to normative data originating from another lab are partially attributable to differences in marker sets, data processing techniques, and consistency of clinicians. Other disparities arise from advances in computer technology, which have dramatically improved motion analysis systems and data processing capability over the last decade. These differences hamper construction of algorithms to separate 'abnormal' individual gait patterns measured at modern labs from normative gait patterns that were established using older technologies and algorithms. Based on this, we began developing a new paediatric database at our lab using modern instrumentation and numerical algorithms. Of interest, were the differences in normative profiles between the two databases and its affect on gait classification results. Therefore, the objective of this study was to provide a method of comparing the sagittal joint angle data between two normative databases. We compared the new database to the historical San Diego database using statistical classifiers.
Method
Participants
Sixty children aged 1–13 years old were recruited from by distributing bulletins campus and local daycare centres. One child was non-compliant during data collection, reducing the sample size to 59 children. These children were divided into two groups: an 'immature' group consisted of 14 children aged less than 3 years, and 2) a 'mature' group contained 45 children aged 3.0 years and older. This age division was based on previous research regarding the onset of mature gait patterns [2]. This assumption was verified using statistical classifiers that could identify mature, normative gait from immature patterns [19]. Ethical approval for this study was obtained from the University Ethics Committee.
Instrumentation/Apparatus
A Vicon 512 motion capture system (Oxford Metrics Ltd.) with six infrared cameras (JAI 60 Hz interlaced) was employed to track the three-dimensional trajectories of reflective markers placed on the subjects' skin. Markers of 25 mm and 14 mm diameter were used depending on body size to reduce crossover and merging. Each trial was subjectively examined for merges or crossovers of marker trajectories. The calibrated volume was approximately 6.7 m × 2.4 m × 1.5 m. Two force plates (Kistler 9281B21, Kistler Instruments, Winterthur, Switzerland and AMTI BP5918, Advanced Mechanical Technology, Incorporated, Newton, MA, USA) collected the three-dimensional ground reaction forces and moments during each gait cycle. Two digital cameras, a weight scale, and calipers were used to obtain anthropometric measures.
Procedures
Marker locations for gait trials
Marker Location for Dynamic Trials |
---|
Left and right anterior superior iliac spine |
Left and right mid-thigh wand |
Left and right lateral femoral condyle |
Left and right mid-shank wand |
Left and right malleolus |
Left and right heel |
Left and right 2nd metatarsal head |
Sacral wand |
Left and right shoulder (midway between neck and acromion process) |
C7, base of neck |
Additional Markers for Static Trials |
Left and right greater trochanter |
Data Analysis
The biomechanical model consisted of the left and right foot, shank, thigh and the pelvis and trunk segments. Embedded coordinate systems were created using the three non-collinear markers on each segment. The segment-based coordinate systems were transformed to the instantaneous, joint center-based, embedded coordinate systems using alignment data from the static capture trial and joint width measurements. Joint center determination, marker configuration, marker alignment, and kinematics data reduction protocol were identical to Davis et al. (1991) with the exception of the following: 1) the heel marker was used during dynamic trials, and 2) an embedded coordinate system was created at the ankle joint using the long axis of the foot (heel – toe), and the transverse axis of the shank segment. In doing so, the flexion axis of the ankle was aligned with the anatomical frontal plane of the shank.
Cadence, velocity, and percent of cycle spent in single stance were calculated for each successful gait cycle. The single gait cycle, which most closely approximated the individual mean of all gait cycles on these three measures (based on an unweighted, least-squares calculation), was selected as the final trial for analysis [2]. Joint angles were computed using Euler angles in a yxz sequence, corresponding to flexion/extension, adduction/abduction, and internal/external rotation. Similar to Sutherland et al. [2], joint angle data were also computed using the projection angle algorithms and then approximated by finite Fourier series using 6 harmonics. Net joint moments and joint power for the hip, knee, and ankle joints were estimated using an inverse dynamics approach. A mathematical model of the human body was used to estimate the segment inertial properties of each child [20]. The required absolute linear and angular velocities and accelerations were calculated from the embedded coordinate systems using a five-point central difference method of derivation [22]. Prior to differentiation, raw coordinate data was filtered using a second order, 6 Hz low-pass Butterworth filter.
Statistical Analysis: Comparisons with San Diego Database
We expected that the classification of UNB normative data using the San Diego mean normative values would not produce accurate results based on the differences in technology and computational methods between the two databases. Therefore, after classifying the UNB gait patterns using the San Diego mean normative values, the gait index classifier was 'recalibrated' so that each UNB normative gait cycle was classified against the UNB mean normative data (instead of San Diego mean data). New values for the interpretable functions and covariance matrix (required for the distance calculation) were computed. New index scores were calculated for the UNB data and the two sets of classification results were compared. The ability of the recalibrated index to detect abnormal gait patterns was tested by computing the gait index for children under the age of 3 years.
A further examination of the differences between the San Diego and UNB normative data sets was conducted using a multivariate analogue of the two-sample t-test [25]. Differences in the mean and covariance structure of the joint angle data from each lab were investigated. These tests compared differences between 1) San Diego projected angle data and UNB Euler angle data, and 2) San Diego projected angle data and UNB projected angle data. To examine whether the sampling methods and Fourier approximations used by Sutherland et al. [2] were responsible for observed differences in sagittal joint angle data between UNB and San Diego, independent t-tests were used to test for mean differences between raw and smoothed San Diego and UNB data.
The classification results of the index scores for the UNB data were compared to those of the more commonly used bootstrap prediction band methods for assessing clinical cases. Bootstrap techniques (B = 500 samples) were applied to the UNB normative data (n = 83 cycles) to establish prediction regions of normal sagittal knee angle data and ninety-five percent prediction regions (m_{ p }= 3.02) were calculated [26]. A knee flexion curve was considered abnormal if any data point was more than 3.02 standard deviations from the mean curve (Figure 1). The classification results obtained using these bootstrap techniques were then compared to the UNB index scores for a clinical case (hypotonic gait).
Results
The classification of sagittal joint angle data (Euler method) for children aged 3–13 years at UNB using the classifier based on San Diego mean normative values, resulted in 49% of 83 cycles being classified as unusual or abnormal. When the gait index was recalibrated using the UNB normative data, the new classification results were similar to those of Tingley et al. [24]: the score behaved like an F_{11,61} statistic for the training data, classifying 94% of cycles as normal (as expected by the nature of the training). Further tests using the gait patterns of younger children showed that the recalibrated classifier was also capable of detecting 82% of immature gait patterns (23 out of 28 cycles) at UNB as unusual or abnormal.
The differences between the two gait index results (49% versus 94% classification) were investigated by comparing the mean and covariance structure of the sagittal angles from each database. Both tests yielded highly significant p-values (p = 0.000). Figure 2 shows the UNB mean hip, knee and ankle joint angle curves (± 2 S.E.) with the San Diego mean normative data superimposed. Although the databases appear similar, the two are quite distinct. For example, the peak mean knee flexion between the two databases is more than 2 standard errors apart. When UNB sagittal joint angles were recalculated using a projected angle approach, mean angle patterns were slightly closer to those of San Diego at the beginning of the cycle and midswing (Figure 3), but were still significantly different (p = 0.000).
Comparison of raw vs smoothed sagittal knee angle across two labs
Database | N | Mean | S.D. | S.E. | |
---|---|---|---|---|---|
RAW DATA | San Diego | 247 | 70.85 | 6.46 | 0.41 |
UNB | 90 | 58.81 | 8.99 | 0.95 | |
FOURIER | San Diego | 243 | 68.40 | 6.24 | 0.40 |
UNB | 90 | 59.49 | 9.67 | 1.02 |
A comparison of the index scores and the bootstrap prediction bands revealed differences in classification results for clinical gait data. Sagittal hip, knee, and ankle angle data for a hypotonic child [19] are shown in Figure 4 with respect to the 95% prediction range. Both knee and ankle data were classified as 'unusual' and 'abnormal' by the UNB index score, but not by the 95% prediction bands. The main reason for the discrepancy in classification between the two methods is that the predictions bands simply analyzed deviations in magnitude and do not consider differences in the pattern of motion. Unless data points deviate from the mean curve by more than 3.02 standard deviations, the child will not be detected. Only a few ankle angle data points extend beyond the boundaries during terminal swing in Figure 4. However, the three graphs show temporal delays in angle data generating a different pattern of motion compared to normative data. The UNB index scores detected this difference in the shape of the curve.
Discussion
Differences in normative gait databases are difficult to assess due to the high-dimensionality and temporal nature of the various kinematic waveforms. The purpose of this study was to provide a method of comparing the sagittal joint angle data between two normative databases. We compared a modern gait database to the historical San Diego database using statistical classifiers developed by Tingley et al. [24]. Differences between the two normative data sets were explored using the index scores, and the mean and covariance structure of the joint angle data from each lab [24]. In addition, the boundaries of normality established by the statistical classifier were compared to Bootstrap methods.
The significant differences found between the San Diego and UNB normative databases are likely due to multiple factors. Since the databases were established over 20 years apart, technological differences are most likely a predominant factor. Sutherland et al. [2] used a pseudo three-dimensional system that consisted of four independent 16 mm motion picture cameras, a Vanguard motion analyzer and a Graf-pen sonic digitizer, requiring the manual digitization of images and joint centers. In contrast, UNB used a three-dimensional system with 6 high-resolution cameras, semi-automatic marker digitization and labeling, and automated joint center estimation techniques.
Changes in data processing techniques over the last two decades are also likely a major cause of differences between the two normative datasets. The results of the multivariate analyses showed that the data sets differ in part due to the algorithms used to calculate the joint angles. UNB's normative data showed more similarity to the San Diego values when joint angles were calculated as projected angles, similar to Sutherland et al. [2], as opposed to Euler angles. In addition, comparisons of sampling rates and smoothing techniques showed that the Fourier approximations were related to decreases in the mean amplitude of the knee angle data. San Diego mean sagittal knee angle data was approximately 9° higher than UNB mean knee angle data when Fourier approximations were compared. In contrast, raw angle comparisons generated a difference of approximately 12°.
Once normative data has been collected, establishing bounds of normality for each gait parameter is necessary. Bootstrap methods may be used to establish prediction bands of normality [26, 27]. This technique captures large point-wise deviations from the mean of the training data set. It does not necessarily capture deviations in patterns of motion, nor does it consider correlations between curves (i.e. knee and ankle angle). The UNB index scores are capable of classifying gait data based on magnitude of deviation, pattern of motion, and correlations between multiple joint angle curves. Therefore, the UNB classifier is able to extract more complex features of each gait cycle that may be missed by bootstrap methods. The finding that the calibrated index of normality identified 80% of cycles for children under 3 years old as unusual or abnormal supports the findings of Tingley et al. [24] that the eleven interpretable functions can successfully classify gait patterns.
Given that only robust sagittal angles were compared in this analysis, it is likely that the differences between labs would be greater for the other planes of motion. The clinical significance of the differences found between the UNB and San Diego databases in this study are uncertain. However, in light of these differences, we will continue efforts to expand the new normative database and retrain the gait classifier as individuals are added.
Declarations
Acknowledgements
The authors wish to gratefully acknowledge the Natural Sciences and Engineering Research Council (NSERC), the New Brunswick Women's Doctoral Scholarship Program, and the Institute of Biomedical Engineering, UNB.
Authors’ Affiliations
References
- Wheelwright EF, Minns RA, Lae HT, Elton RA: Temporal and spatial parameters of gait in children. I: Normal control data. Dev Med Child Neurol. 1993, 35 (2): 102-13.PubMedView ArticleGoogle Scholar
- Sutherland DH, Olshen RA, Biden EN, Wyatt MP: The Development of Mature Walking. 1988, London: MacKeith PressGoogle Scholar
- Hennessey MJ, Dixon SD, Simon SR: The development of gait: a study in African children aged one to five. Child Dev. 1984, 55: 844-53. 10.2307/1130135.View ArticleGoogle Scholar
- Norlin R, Odenrick P, Sandlund B: Development of gait in the normal child. J Pediatr Orthop. 1981, 1: 261-6.PubMedView ArticleGoogle Scholar
- Scrutton DR: Footprint sequences of normal children under five years old. Dev Med Child Neurol. 1969, 11: 44-53.PubMedView ArticleGoogle Scholar
- Grieve DW, Gear RJ: The relationships between length of stride, step frequency, time of swing and speed of walking for children and adults. Ergonomics. 1966, 5 (9): 379-99. 10.1080/00140136608964399.View ArticleGoogle Scholar
- Grimshaw PN, Marques-Bruna P, Salo A, Messenger N: The 3-dimensional kinematics of the walking gait cycle of children aged between 10 and 24 months: cross sectional and repeated measures. Gait and Posture. 1998, 7: 7-15. 10.1016/S0966-6362(97)00025-8.PubMedView ArticleGoogle Scholar
- Sutherland DH: The development of mature gait. Gait and Posture. 1997, 6: 163-70. 10.1016/S0966-6362(97)00029-5.View ArticleGoogle Scholar
- Kadaba MP, Ramakrishnan HK, Wooten ME: Measurement of lower extremity kinematics during level walking. J Orthop Res. 1990, 8: 383-92. 10.1002/jor.1100080310.PubMedView ArticleGoogle Scholar
- Schwartz M: Kinematics of normal gait. The Treatment of Gait Problems in Cerebral Palsy. Edited by: Gage JR. 2004, London: MacKeith Press, 99-119.Google Scholar
- Starr R, Barwood S, Rodda J, Graham K: A new model of three dimensional trunk kinematics. Fifth Annual Gait and Clinical Movement Analysis Meeting, Mayo Clinic, Rochester, Minnesota, USA. April 12–15, 2000.
- Ganley KJ, Powers CM: Gait kinematics and kinetics of 7-year-old children: a comparison to adults using age-specific anthropometric data. Gait and Posture. 2005, 21 (2): 141-145. 10.1016/j.gaitpost.2004.01.007.PubMedView ArticleGoogle Scholar
- Cupp T, Oeffinger D, Tylkowski C, Augsburger S: Age-related kinetic changes in normal pediatrics. J Pediatr Orthop. 1999, 19: 475-8. 10.1097/00004694-199907000-00010.PubMedView ArticleGoogle Scholar
- Oeffinger D, Brauch B, Cranfill S, Hisle C, Wynn C, Hicks R, Augsburger S: Comparison of gait with and without shoes in children. Gait and Posture. 1999, 9: 95-100. 10.1016/S0966-6362(99)00005-3.PubMedView ArticleGoogle Scholar
- Oeffinger DJ, Augsburger MS, Cupp T: Pediatric Kinetics: Age-related changes in able-bodied populations. Gait and Posture. 1997, 5 (2): 155-156. 10.1016/S0966-6362(97)83380-2.View ArticleGoogle Scholar
- Ounpuu S, Davis RB, DeLuca PA: Joint kinetics: methods, interpretation and treatment decision-making in children with cerebral palsy and myelomeningocele. Gait and Posture. 1996, 4 (1): 62-78. 10.1016/0966-6362(95)01044-0.View ArticleGoogle Scholar
- Ounpuu S, Gage JR, Davis RB: Three-dimensional lower extremity joint kinetics in normal pediatric gait. J Pediatr Orthop. 1991, 11: 341-9.PubMedView ArticleGoogle Scholar
- Davis RB, Ounpuu S: Kinetics of normal gait. The Treatment of Gait Problems in Cerebral Palsy. Edited by: Gage JR. 2004, London: MacKeith Press, 120-134.Google Scholar
- Chester VL, Tingley M, Biden EN: An extended index to quantify normality of gait in children. Gait & Posture (Accepted, Available Online, July 2006). 2007, 25 (4): 549-554. 10.1016/j.gaitpost.2006.06.004.View ArticleGoogle Scholar
- Sun H, Jensen RK: Body segment growth during infancy. Journal of Biomechanics. 1994, 27 (3): 265-275. 10.1016/0021-9290(94)90003-5.PubMedView ArticleGoogle Scholar
- Davis RB, Ounpuu S, Tyburski D, Gage JR: A gait data collection and reduction technique. Human Movement Science. 1991, 10: 575-587. 10.1016/0167-9457(91)90046-Z.View ArticleGoogle Scholar
- Burden RL, Faires JD: Numerical analysis. 1985, New York: Brooks/Cole Publishing CompanyGoogle Scholar
- Biden EN, Olshen RA, Sutherland DH, Gage J, Kadaba M: Comparison of gait data from multiple labs. Transactions of the Orthopaedic Research Society. 1987Google Scholar
- Tingley M, Wilson C, Biden EN, Knight W: An index to quantify normality of gait in young children. Gait and Posture. 2002, 16: 149-158. 10.1016/S0966-6362(02)00012-7.PubMedView ArticleGoogle Scholar
- Seber G: Multivariate Observations. 1984, New York: John Wiley & SonsView ArticleGoogle Scholar
- Olshen RA, Biden EN, Wyatt MP, Sutherland DH: Gait analysis and the bootstrap. Annals of Statistics. 1989, 17 (4): 1419-40.View ArticleGoogle Scholar
- Lenhoff MW, Santner TJ, Otis JC, Peterson MGE, Williams BJ, Backus SI: Bootstrap prediction methods and confidence bands: a superior statistical method for analysis of gait data. Gait and Posture. 1999, 9: 10-17. 10.1016/S0966-6362(98)00043-5.PubMedView ArticleGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.